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KMID : 0389420040120030017
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Korean Journal of Stress Research
2004 Volume.12 No. 3 p.17 ~ p.20
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Kim Sun-Mee
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Abstract
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Stress embraces the reaction to a multitude of poorly defined factors that disturb homeostasis. The activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system has been utilized as objective measurements of stress reactions. Repeated activation of these two stress centres may be involved in the pathogenesis of abdominal obesity and its comorbidities. In population studies adrenal hormones show strong statistical associations to centralization of body fat as well as to obesity. There is considerable evidence from clinical to cellular and molecular studies that elevated cortisol, is causing accumulation of fat in visceral adipose tissues. Glucocorticoid exposure is also followed by increased food intake and leptin resistant obesity perhaps disrupting the balance between leptin and neuropeptide Y to the advantage of the latter. Factors activating the stress centres in humans include psychosocial and socioeconomic handicaps, depressive and anxiety traits, alcohol and smoking, with some differences in profile between personalities and genders.
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KEYWORD
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Stress, Obesity, Adrenal hormones, Leptin, Neuropeptide Y
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